These are the fibrates, bile acid sequestrants, intestinal absorption blockers and niacin. In addition to statins, your doctor may select a medication from the other four types of cholesterol-lowering medications. Nicotinic acid works by blocking the formation of LDL, the bad cholesterol, and decreasing the production of VLDL in the liver. It raises HDL to a greater degree--15 to 35 percent--and decreases LDL by 5 to 25 percent. You mainly take them to lower triglycerides. In addition to statins, your doctor may select a medication from the other four types of cholesterol-lowering medications. constipation. Bile acid sequestrants cause constipation, abdominal pain, bloating and gas. This type of cholesterol particle carries fat in the blood called triglycerides. © 2005 - 2019 WebMD LLC. They don’t do much to lower LDL though. In others, side effects such as muscle pain, or liver problems, make it too hard to take statins. They may also cause liver damage, especially when combined with a statin. Aside from Zetia there haven’t been any good non-statin options for lowering LDL Cholesterol. The non-statin cholesterol-lowering medications are also effective at lowering LDL but to a lesser extent. pain or tenderness around the eyes and cheekbones. Scientists also are researching new types of medicines that can bring down cholesterol. Other medications can lower “bad” LDL cholesterol and increase “good” HDL cholesterol, which can lower your risk for heart attacks and strokes. Quiz: What You Need to Know About Cholesterol Medicines. Non Statin Cholesterol Lowering Drugs You are at a point where your cholesterol level exceeds the standards set by your life or health insurance company (higher premiums or outright denial of coverage) or perhaps your potential employer refuses to hire you for the same reasons. They “have been developed for people who are not at their goal cholesterol despite current treatments,” Cannon says. The only intestinal absorption blocker currently on the market as of 2010 is ezetimibe (Zetia). Copyright © 2020 Leaf Group Ltd., all rights reserved. Sign Up to Receive Our Free Coroanvirus Newsletter, Alternative Treatments for High Cholesterol, Diabetes? Like the fibrates, it lowers TG by 20 to 50 percent. They are most effective for lowering triglycerides (TG). The bile-acid sequestrants decrease LDL by 15 to 30 percent of baseline numbers. Examples of fibrates are fenofibrate (Tricor) and gemfibrozil (Lopid). All rights reserved. Statin drugs like Lipitor (atorvastatin), Zocor (simvastatin) and Crestor work well to lower the “bad” cholesterol, the LDL, and have remained first line therapy for many years. High cholesterol is one of a number of risk factors for developing heart disease, which is the number one cause of death among Americans in 2010. Ezetimibe works by blocking the absorption of dietary cholesterol in the intestine. Niacin, a B vitamin, affects how your body makes blood fats and can also lower LDL. muscle pain, tenderness, or weakness. It's also available as an extended-release prescription formulation called Niaspan. Nicotinic acid works by blocking the formation of LDL, the bad cholesterol, and decreasing the production of VLDL in the liver. . The first-line agents are the statins. Niacin or nicotinic acid is a B vitamin and is available over the counter 1. lower back or side pain. Christopher Cannon, MD, professor, Harvard Medical School; senior physician, Brigham and Women’s Hospital. They decrease them by 20 to 50 percent and at the same time, increase HDL by 10 to 35 percent. Bile acid sequestrants cause constipation, abdominal pain, bloating and gas. These are the fibrates, bile acid sequestrants, intestinal absorption blockers and niacin. Chances are the first thing they’ll prescribe is a statin. Finally, there may be something new to get excited about. "Drug Information Handbook"; Charles Lacy, Lora Armstrong, Morton Goldman, Leonard Lance; 2008. There are many non-statin medications your doctor might prescribe: Bile acid-binding resins, like cholestyramine (Locholest, Prevalite, Questran), colesevelam (WelChol), and colestipol (Colestid) stick to cholesterol-rich bile acids in your intestines and lower your LDL levels. Each class of cholesterol-lowering medication works in a different way.

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